منابع مشابه
16-Substituted steroids. XV. A new synthetic method for 16-ketosteroids.
In 1941 (1) the senior author entered the field of 16-substituted steroids with the view of preparing all of the three possible 16,17-epimers of natural estriol. Since that time two of these three epimers, 16-epiestriol (isoestriol-A) (2) and 17-epiestriol (3), have become available through our efforts and those of the Swiss investigators. In 1952 the present authors made an attempt to prepare ...
متن کامل16-substituted Steroids Iii. the Partial Synthesis of Estriol by Max N. Huffman
Estriol was originally obtained (1930) by isolation from human pregnancy urine by Marrian (1) and by Doisy et al. (2). Both Doisy (2) and Marrian (3) showed that estriol differed from estrone, another estrogenic hormone occurring in gravid urine, in possessing three acetylizable hydroxyl groups instead of the one hydroxyl and one carbonyl. Butenandt (4) soon (1931) proved that estriol might be ...
متن کاملMetabolism of C-16-oxygenated steroids by human placenta: the formation of estriol.
Two distinct pathways for the formation of estriol in vitro have recently been described: C-16 hydroxylation of estradiol-17-P by human fetal liver and rat liver (1, 2), and aromatization of A5-androstene-3/?, 16a, 17&triol by human placenta (3). Although the formation in viva of estriol from estradioll and estrone is well known (4), the studies mentioned above present the first convincing data...
متن کاملFactors regulating the concentrations of 16-androstene steroids in submaxillary salivary glands of pigs.
The measurement of 16-androstene steroids in submaxillary salivary glands is a potentially good way to estimate boar taint. The objective of this work was to identify factors regulating the concentrations of these steroids in salivary glands. Large White x Pietrain male pigs were divided into four treatments: T-1, intact untreated (n = 18); T-2, intact treated with porcine somatotropin (pST, n ...
متن کاملNew steroid haptens for radioimmunoassay: synthesis of steroids substituted with thioether or ester linkages at the 2 alpha-position.
Haptens with bridge at the 2-position have not yet been explored. Radioimmunoassays with antibodies directed against 2 alpha-alkyl bridged steroid haptens are expected to be highly specific due to greater topographical exposure and similarity in conformation to the native steroid. The 2 alpha-alkyl bridged haptens were synthesized by first adding a cyclopropane ring to 2-methylene-4-en-3-one. S...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1948
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)52768-5